netilmicin sulfate
netilmicin sulfate
CAS: 56391-57-2
Molecular Formula: C42H92N10O34S5
netilmicin sulfate - Names and Identifiers
| Name | netilmicin sulfate |
| Synonyms | netromycin netilmicin sulfate Sulfate NetilMicin Netilmicin sulfhate Netilmicin Sulphate netilmycin sulphate Netilmicin sulphate, 1-N-Ethylsisomicin 6-diamino-2,3,4,6-tetradeoxy-alpha-d-glycero-hex-4-enopyranosyl-(1-4)-6)-o-( |
| CAS | 56391-57-2 |
| EINECS | 260-147-3 |
| InChI | InChI=1/2C21H41N5O7.5H2O4S/c2*1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20;5*1-5(2,3)4/h2*5,11-20,25-29H,4,6-9,22-24H2,1-3H3;5*(H2,1,2,3,4)/t2*11-,12+,13-,14+,15-,16-,17+,18-,19-,20-,21+;;;;;/m11...../s1 |
netilmicin sulfate - Physico-chemical Properties
| Molecular Formula | C42H92N10O34S5 |
| Molar Mass | 1441.55 |
| Melting Point | >194°C (dec.) |
| Boling Point | 868℃ |
| Flash Point | 367.7°C |
| Water Solubility | Soluble in water |
| Solubility | H2O: soluble10mg/mL |
| Vapor Presure | 1.1E-21mmHg at 25°C |
| Appearance | Solid |
| Color | white to faint yellow |
| Storage Condition | Inert atmosphere,2-8°C |
| Stability | Hygroscopic |
| Sensitive | Light Sensitive & Hygroscopic |
| Use | Suitable for the treatment of severe infections caused by sensitive Gram-negative bacilli |
| In vitro study | Netilmicin Sulfate is a semisynthetic derivative of sisomicin. Bacteria resistant to aminoglycoside antibiotics, it has Resistance activity and, relative to sisomicin, gentamicin and tobramycin, greatly reduces chronic toxicity in animals. Netilmicin Sulfate has high resistance activity against Escherichia Coli, Klebsiella spp., Enterobacter spp., Citrobacter, Proteus and Staphylococcus aureus. In addition, 87% indole-positive Proteus strains, 90.7% Serratia spp. And 83.5% Pseudomonas aeruginosa strains were sensitive to Netilmicin Sulfate. |
netilmicin sulfate - Risk and Safety
| Risk Codes | R61 - May cause harm to the unborn child R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R60 - May impair fertility |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | WK2286000 |
| HS Code | 2941906000 |
netilmicin sulfate - Upstream Downstream Industry
netilmicin sulfate - Reference
| Reference Show more | 1. Li, Jun, et al. "A Light-Up Strategy with Aggregation-Induced Emission for Identification of HIV-I RNA-Binding Small Molecules." Analytical Chemistry 92.19 (2020): 13532-13538.https://doi.org/10.1021/acs.analchem.0c03010 2. [IF=6.986] Jun Li et al."A Light-Up Strategy with Aggregation-Induced Emission for Identification of HIV-I RNA-Binding Small Molecules."Anal Chem. 2020;92(19):13532–13538 |
netilmicin sulfate - Nature
Open Data Verified Data
white crystalline powder, soluble in water, its aqueous solution is more stable.
Last Update：2024-01-02 23:10:35
netilmicin sulfate - Quality standards-Chinese Pharmacopoeia 2005 edition
Open Data Verified Data
netilmicin sulfate: calculated as anhydrous, the titer per 1mg should not be less than 610 units of nesidin; The clarity and color of the solution should comply with the regulations; The pH value should be 3. 5~5.5(40mg of this product is soluble in 1 ml of water) I the sulfate content should be 31.5% ~
calculated as anhydrous
35.o%; Related substances shall be in accordance with the regulations; Water content shall not exceed 15.o%; Ignition residue shall not exceed 1.0%; Heavy metals shall not exceed 0.002%, abnormal toxicity should be in accordance with the provisions of I the amount of endotoxin per 1000 units of netilmicin should be less than 1. 25EU.
Last Update：2022-01-01 08:52:44
netilmicin sulfate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.387 ml | 6.937 ml | 13.874 ml |
| 5 mM | 0.277 ml | 1.387 ml | 2.775 ml |
| 10 mM | 0.139 ml | 0.694 ml | 1.387 ml |
| 5 mM | 0.028 ml | 0.139 ml | 0.277 ml |
Last Update：2024-01-02 23:10:35
netilmicin sulfate - Preparation Method
Open Data Verified Data
obtained by fermentation and purification of N-ethyl-α-deoxy-D-streptavidin.
Last Update：2022-01-01 08:52:44
netilmicin sulfate - Use
Open Data Verified Data
is a derivative of the aminoglycoside antibiotic West. The antibacterial spectrum was similar to that of gentamicin, tobramycin, sifusomycin and amikacin, but it was more effective against Staphylococcus aureus and intestinal bacteria, but it was slightly less effective against Pseudomonas aeruginosa and provideria. The resistance to Pseudomonas aeruginosa is not as good as to sifusomycin, tobramycin, amikacin, gentamicin. Its advantage is the auditory nerve and kidney toxicity than the clinical commonly used aminoglycoside antibiotics for small, gentamicin resistant intestinal bacteria and Pseudomonas aeruginosa have high efficiency. Mainly used for Escherichia coli, Klebsiella, Proteus, Enterobacter, citric acid bacteria, Serratia, Haemophilus influenzae, Salmonella, Shigella, neisseria and other Gram-negative bacteria caused by respiratory tract, digestive tract, genitourinary system, skin and soft tissue, bone and joints, abdominal cavity, trauma and other parts of the infection, also applies to sepsis.
Last Update：2022-01-01 08:52:45
netilmicin sulfate - Safety
Open Data Verified Data
mouse intravenous injection, intraperitoneal injection, subcutaneous injection of LDso (mg/kg):40, 125, 175.
Last Update：2022-01-01 08:52:45
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Spot supply
Product Name: Netilmicin Sulfate Visit Supplier Webpage Request for quotationCAS: 56391-57-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Raw Materials for netilmicin sulfate